Slemmer's murder created a media frenzy in Knoxville, Tennessee in 1995, when the teen was found with a pentagram - a symbol that is associated with satanic groups - carved into her chest. Pike has denied carving the pentagram herself.
She had accused Slemmer of insulting her and trying to steal her boyfriend. Two other residents at the camp later testified that Pike had bragged about the murder before and after, and showed them a piece of Slemmer's skull.
Her attorneys have argued that "an 18-year-old brain is not an adult brain" and that Pike was too young at the time of the murder to be sentenced to death for it.
At the time of her incarceration, Pike was the youngest person on death row, according to the Tennessee Department of Corrections.
She is due to be executed at 11:00 EDT (15:00 GMT) on Wednesday at Riverbend Maximum Security Institution in Nashville.
Additional reporting from Sareen Habeshian.
Clarification 29 September: This article originally referred to a pentagram as "a symbol of Satanic ritual". We have amended the wording to make clear that the symbol in question was an inverted pentagram and to clarify that such symbols are associated with some satanic groups. The article has been updated accordingly.